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14 January 2012 in News / no comment

The National Toxicology Program Interagency Center for purchase Lexapro pay pal online without rx the Evaluation of Alternative Toxicological Methods (NICEATM) announces availability of the report on the “International Workshop on Alternative Methods To Reduce, Refine, and purchase Lexapro pay pal online without rx Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the purchase Lexapro pay pal online without rx Science and Future Directions”.

The report was published as a purchase Lexapro pay pal online without rx dedicated issue of the journal Procedia in Vaccinology (Volume 5, pp 1-266, 2011) and is publicly available on the journal’s website at http://www.sciencedirect.com/science/journal/1877282X. A limited number of CD and purchase Lexapro pay pal online without rx paper copies of the report are available from NICEATM (see contact information below).

Background

Regulatory authorities require testing of vaccines to purchase Lexapro pay pal online without rx ensure their safety and effectiveness. However, such testing requires large numbers of animals and purchase Lexapro pay pal online without rx accounts for the majority of animals reported to the USDA with unrelieved pain and purchase Lexapro pay pal online without rx distress. Accordingly, identification and promotion of alternative methods that can purchase Lexapro pay pal online without rx reduce, refine (enhance animal well-being and lessen or avoid pain and distress), and purchase Lexapro pay pal online without rx replace the use of animals for vaccine potency and safety testing is purchase Lexapro pay pal online without rx one of the four highest priorities of the Interagency Coordinating Committee on the purchase Lexapro pay pal online without rx Validation of Alternative Methods (ICCVAM), an interagency committee of the Federal government administered by NICEATM.

The “International Workshop on Alternative Methods to purchase Lexapro pay pal online without rx Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and purchase Lexapro pay pal online without rx Safety Testing: State of the Science and Future Directions” was convened in September 2010 to purchase Lexapro pay pal online without rx review the state of the science of available alternative methods for purchase Lexapro pay pal online without rx human and veterinary vaccine potency and safety testing and to identify specific R&D activities necessary to purchase Lexapro pay pal online without rx advance test methods with the potential to further reduce, refine, and purchase Lexapro pay pal online without rx replace animal use for vaccine testing.

Workshop Report and Outcomes

The workshop report is purchase Lexapro pay pal online without rx comprised of 27 papers that summarize plenary session presentations and the purchase Lexapro pay pal online without rx conclusions and recommendations developed by the workshop participants during six breakout group sessions. The report recommends vaccines that purchase Lexapro pay pal online without rx should have the highest priority for future reduction, refinement, and replacement efforts. Other key recommendations include:

• Procedures such as earlier humane endpoints should be purchase Lexapro pay pal online without rx developed and implemented immediately to reduce or avoid the pain and purchase Lexapro pay pal online without rx distress experienced by animals for vaccines that still require live-agent challenge testing. Until non-animal tests are purchase Lexapro pay pal online without rx available, development of serological assays should also be considered as a purchase Lexapro pay pal online without rx way to avoid challenge testing.
• Specific non-animal approaches that purchase Lexapro pay pal online without rx have successfully replaced animals for some vaccine potency testing should be purchase Lexapro pay pal online without rx developed for vaccines currently requiring animals through identification, purification, and characterization of vaccine protective antigens.
• International harmonization and purchase Lexapro pay pal online without rx cooperation efforts and closer collaborations between human and veterinary vaccine researchers should be purchase Lexapro pay pal online without rx enhanced to support more rapid progress towards reduction, refinement, and replacement of animal use for purchase Lexapro pay pal online without rx vaccine testing.

The workshop was organized by NICEATM and purchase Lexapro pay pal online without rx ICCVAM and sponsored by the National Institute of Environmental Health Sciences and purchase Lexapro pay pal online without rx the National Toxicology Program. It was cosponsored by the European Centre for purchase Lexapro pay pal online without rx the Validation of Alternative Methods, the Japanese Center for the Validation of Alternative Methods, and purchase Lexapro pay pal online without rx Health Canada, along with the Society of Toxicology.

Information about the purchase Lexapro pay pal online without rx workshop can be found on the NICEATM-ICCVAM website at http://iccvam.niehs.nih.gov/meetings/BiologicsWksp-2010/BiologicsWksp.htm. This page also contains a purchase Lexapro pay pal online without rx link to the online workshop report, which is available to the purchase Lexapro pay pal online without rx public.

Copies of the purchase Lexapro pay pal online without rx workshop report can also be obtained by contacting NICEATM at niceatm@niehs.nih.gov.

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